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Quantifying 3D Traction Forces of Epithelial Cell Clusters

When cells assemble together in a
cluster, they apply force to each other.
The way in which cells signal each
other with and respond to forces is not
well understood. Therefore, we study
the traction forces cells apply to the
substrate beneath them. The results
show exterior cells apply tractions to
the substrate that are an order of
magnitude larger than the tractions
the interior cells apply.