The human genome is a highly
complex multi-scale material that is composed of nucleic acids and
proteins. The mechanical properties
of our genomes play essential roles in
its function. Unfortunately, the
structure and dynamics of the human genome is not well-understood and is a
major limitation it determining how it functions.
Ohio State researchers are
developing three complimentary magnetic resonance based methods to probe the
structure and dynamics of short sections of the genome called chromatin. Solid
State Nuclear Magnetic Resonance is being developed to probe chromatin structure,
Electron Paramagnetic Resonance is being developed to probe chromatin
dynamics. And Optically Detected
Magnetic Resonance is being developed for single molecule magnetic resonance
studies of chromatin dynamics.
